Body Mass Index Drives Changes in DNA Methylation
نویسندگان
چکیده
منابع مشابه
DNA methylation and body-mass index: a genome-wide analysis
BACKGROUND Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between several genetic variants and body-mass index (BMI) have been identified, little is known about epigenetic changes related to BMI. We undertook a genome-wide analysis of methylation at CpG sites in relation to BMI. METHODS 479 in...
متن کاملEffect of Body Mass Index on Global DNA Methylation in Healthy Korean Women
Obesity is known to be strongly associated with cardiovascular disease and cancer, the leading causes of mortality worldwide, and develops owing to interactions between genes and the environment. DNA methylation can act as a downstream effector of environmental signals, and analysis of this process therefore holds substantial promise for identifying mechanisms through which genetic and environm...
متن کاملTemporal Changes in Lipid Profile and Anthropometric Parameters According to Body Mass Index, Among Iranian Adults
Introduction: The aim of this study was to examine in the lipid profile during 3.6 years and anthropometric parameters in Iranian adults the changes during 3.6 year body mass index (BMI). Materials and methods: Among participants of the Tehran lipid and glucose study (TLGS), 2940 non-diabetic adults, aged 20 years and older, who remained within the same BMI group during the two phases of the su...
متن کاملAsthma and body mass index in occupational setting
Background :Asthma is the most common respiratory disease with an increasing prevalence. On the other hand, obesity is also a challenging disease compromising health in human communities. This study sought to assess the correlation of asthma and body mass index (BMI) in occupational setting. Methods : This study was conducted in a cable manufacturing company in 2012. A total of 551 workers ...
متن کاملMUC1-C drives DNA methylation in cancer
publications have reported a previously unrecognized role for the MUC1-C oncoprotein in regulating DNA methyltransferase (DNMT) expression and thereby DNA methylation in human cancer cells [1, 2]. The MUC1-C transmembrane protein is aberrantly overexpressed in diverse human cancers and in certain hematologic malignancies, including acute myelo-genous leukemia (AML) [3]. Dysregulation of DNMTs a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2019
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.119.315397